Charlotte Ling

Memorial Sloan Kettering Cancer Center, Johns Hopkins University

Papers

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About

Charlotte Ling is a pioneering researcher in the field of image-guided robotics for small animal studies, with a focus on advancing precision medicine in oncology. Her key research areas include the development of robotic systems for targeted intratumoral measurements, biopsy, and therapeutic injections in rodent models. Ling’s major contributions lie in creating highly accurate, image-guided robots that integrate PET and other imaging modalities to guide needles for oxygen tension (pO2) measurement, tissue sampling, and adenoviral sequence delivery. Her most-cited work, a 2009 paper on a robotic system for FMISO PET-guided intratumoral measurements (34 citations), demonstrates the practical application of this technology in mapping tumor hypoxia, a critical factor in cancer treatment resistance. Earlier foundational papers, such as her 2007 study on robot development for small animal research (16 citations) and her 2004 design for measurement, biopsy, and injection (8 citations), established the framework for millimeter-scale precision in rodent models. Ling’s work has significantly impacted preclinical cancer research by enabling reproducible, image-guided interventions, bridging the gap between imaging and physical manipulation. Her achievements highlight a commitment to translational tools that enhance the accuracy of experimental oncology, making her a key figure in biomedical robotics.