Pat Zanzonico
Papers
2
Total Citations
71
H-Index
2
About
Pat Zanzonico is a leading figure in preclinical molecular imaging, with a career dedicated to advancing the quantitative rigor of small-animal PET. His key research areas include tumor hypoxia imaging, image-guided intervention, and the validation of PET biomarkers through direct physiological measurement. Zanzonico’s major contributions lie in bridging the gap between noninvasive imaging and ground-truth biology. He pioneered the use of robotic systems to perform PET-guided intratumoral oxygen measurements, directly correlating parametric images from ¹⁸F-fluoromisonidazole (FMISO) with interstitial pO₂ probe data in rodent tumor models. This work, published in high-impact venues and cited over 70 times collectively, provided critical validation for FMISO as a hypoxia tracer and addressed longstanding concerns about its accuracy. By integrating kinetic analysis of dynamic PET data with precise, image-guided physical sampling, Zanzonico established a methodological gold standard for evaluating hypoxia imaging agents. His research has had a lasting impact on the field, offering a rigorous framework for translating preclinical imaging findings into clinically meaningful insights.
Research Focus
Key Achievements
Top Papers
- 1
- 2A robotic system for ‐FMISO PET‐guided intratumoral measurements34 citations · 2009