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About

Brian M. Paegel is a pioneering researcher at the intersection of microfluidics, chemical biology, and high-throughput drug discovery. His career spans two complementary frontiers: advancing microfabricated separation technologies for genomic analysis and developing innovative microfluidic platforms for bioactive compound discovery. Paegel's early work revolutionized DNA sequencing and genetic analysis through microfabricated capillary array electrophoresis (microCAE), with his landmark 2003 paper on microfluidic DNA sequencing devices accumulating over 200 citations. His development of high-performance microCAE systems and supporting instrumentation, including rotary scanning confocal fluorescence detectors and high-pressure gel loaders, helped establish the technological foundation for modern genomic analysis pipelines. In more recent years, Paegel has pushed the boundaries of drug discovery by integrating DNA-encoded library (DEL) screening with activity-based assays and droplet microfluidics. His work on microfluidic bead suspension hoppers, emulsion creamers, and DEL screening platforms demonstrates a sustained commitment to replacing costly robotic automation with elegant, miniaturized solutions. With nearly 450 cumulative citations across his key works, Paegel's contributions have meaningfully shaped both genomics instrumentation and the emerging landscape of ultra-high-throughput chemical screening, making him an influential figure for researchers in analytical chemistry and chemical biology alike.