Brad Larson
Papers
3
Total Citations
34
H-Index
3
About
Brad Larson is a leading figure in laboratory automation, with a career dedicated to transforming complex biological assays into high-throughput, reliable processes for drug discovery. His primary research areas center on automating critical ADME/Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity) workflows, particularly those involving cell-based assays and molecular biology sample preparation. Larson’s major contribution lies in bridging the gap between manual, low-throughput science and industrial-scale efficiency. His most cited work, "Automation of Cell-Based Drug Absorption Assays in 96-Well Format Using Permeable Support Systems" (2012, 22 citations), directly addressed a bottleneck in drug development by enabling robust, automated permeability testing with Caco-2 and MDCK-MDR1 cell lines, a key determinant for advancing lead compounds. He further advanced toxicology screening with a triplexed hepatocyte assay for CYP1A and -3A induction (2011, 6 citations), providing a more holistic view of drug metabolism and toxicity. Demonstrating versatility, his earlier work on automated PCR product purification using paramagnetic particles (2002, 6 citations) streamlined a fundamental molecular biology step. Through these innovations, Larson has significantly increased the throughput and reproducibility of essential preclinical assays, making him a pivotal figure in modern laboratory automation.
Research Focus
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