Ayelet Lesman

Papers

Total Citations

H-Index

About

Ayelet Lesman is a pioneering researcher in the field of mechanobiology and tissue engineering, with a focus on how physical cues—such as microtopography and mechanical forces—regulate cell behavior and tissue formation. Her work bridges engineering and biology to create functional muscle actuators and vascularized tissues. Notably, her 2025 study on "Leveraging microtopography to pattern multi-oriented muscle actuators" introduces STAMP, a cost-effective method using 3D-printed stamps to create precise microtopographical patterns on hydrogels. This technique enables controlled alignment of mouse and human muscle cells, advancing the development of complex, multi-oriented muscle tissues for regenerative medicine and biohybrid robotics. With over 14 citations already, this work underscores her impact in accessible, scalable tissue engineering. Lesman’s broader contributions include elucidating how substrate stiffness and geometry influence stem cell differentiation and tissue self-organization, earning her recognition as a leader in mechanobiology. Her innovative approaches continue to inspire students and researchers seeking to harness physical microenvironments for therapeutic applications.