Papers
3
Total Citations
137
H-Index
3
About
Annelaure Damont is a leading radiochemist whose work has profoundly advanced the field of neuroinflammation imaging through the development of novel positron emission tomography (PET) radiotracers. Her primary research focuses on the design and radiosynthesis of fluorine-18 labeled ligands targeting the translocator protein (TSPO, 18 kDa), a key biomarker for activated microglia in neurological disorders. Damont’s most impactful contribution is the radiosynthesis of [¹⁸F]DPA-714, a selective TSPO radioligand that has become a widely used tool for imaging neuroinflammation in conditions such as Alzheimer’s disease, stroke, and multiple sclerosis. This seminal work, published in 2008, has garnered 88 citations, underscoring its importance. She has also developed other critical TSPO-targeting tracers, including [¹⁸F]PBR111 and [¹⁸F]fluoro-PBR28, expanding the toolkit for in vivo TSPO imaging. Her methodological innovations, often employing automated synthesis platforms like the Zymate-XP robot, have enabled reproducible and efficient tracer production. Damont’s contributions have directly facilitated both preclinical and clinical studies, making her a pivotal figure in molecular imaging and a key enabler of translational research into neuroinflammatory diseases.
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