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About
Tien Pham is a leading figure in radiochemistry and molecular imaging, with a focused expertise in the development of novel radioligands for positron emission tomography (PET). Their seminal work centers on the radiosynthesis of [¹⁸F]PBR111, a high-affinity and selective radioligand designed to image the translocator protein (TSPO, 18 kDa). This protein is a critical biomarker for neuroinflammation, making Pham’s contributions vital for advancing the diagnosis and study of neurological disorders. The landmark 2008 paper detailing this synthesis, which has garnered 19 citations, showcases Pham’s pioneering use of automated robotic platforms—specifically the Zymate-XP robot—to achieve efficient and reproducible fluorine-18 labeling. This methodological innovation not only streamlined the production of [¹⁸F]PBR111 but also set a standard for automated radiosynthesis in the field. Pham’s work has had a lasting impact on PET imaging, providing researchers with a powerful tool to non-invasively visualize and quantify TSPO expression, thereby enabling critical insights into conditions such as Alzheimer’s disease, multiple sclerosis, and traumatic brain injury. Their achievements underscore a career dedicated to bridging synthetic chemistry and clinical neuroscience.
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