Ann M. Ferrie

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About

Ann M. Ferrie is a pioneer in the development of high-throughput screening technologies for drug discovery, with a primary focus on membrane protein biochips and protein microarray fabrication. Her seminal 2002 work, "Membrane Biochips," which has garnered 13 citations, laid critical groundwork for addressing the formidable challenge of immobilizing membrane-bound proteins—the most important class of drug targets—on microarray surfaces. In this study, Ferrie demonstrated the feasibility of using conventional robotic pin printing to fabricate functional G protein-coupled receptor (GPCR) arrays, enabling direct observation of ligand binding selectivity and specificity. Her subsequent 2005 paper on "Production of Protein Microarrays Using Robotic Pin Printing Technologies" (4 citations) further refined these methods, offering practical solutions for parallel analysis of multiple drug targets in response to the growing demand from genomics-based approaches. Ferrie’s contributions have been instrumental in bridging the gap between genomic data and functional proteomics, providing researchers with robust tools for cost-effective target validation and drug screening. Her work remains a foundational reference for scientists developing array-based platforms for membrane protein analysis.