A. Hari Reddi

Papers

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About

A. Hari Reddi is a pioneering researcher in tissue engineering and regenerative medicine, with a focused expertise in hepatic biology and growth factor-mediated control of cellular phenotype. His major contributions center on the innovative use of micropatterned, growth factor-encoded surfaces to precisely modulate liver cell behavior in vitro. Reddi’s seminal work demonstrated that hepatocytes cultured on robotically printed arrays of hepatocyte growth factor (HGF) and bone morphogenetic protein 7 (BMP7) exhibit enhanced viability and protective effects against alcohol-induced injury, a finding with significant implications for liver disease modeling and drug screening. His 2009 study on cultivating liver cells on printed HGF arrays (46 citations) and his 2010 follow-up characterizing protective effects during alcohol injury (41 citations) are among his most impactful, establishing a novel platform for local control of hepatic phenotype. His 2013 work further explored how surfaces encoded with HGF or TGF-β1 can direct hepatocyte phenotype expression. Reddi’s research bridges materials science and cell biology, offering a powerful tool to study liver regeneration and toxicity without systemic growth factor exposure, advancing the field toward more physiologically relevant culture systems.