Zhengping Ma
Papers
1
Total Citations
11
H-Index
1
About
Zhengping Ma is a distinguished researcher in metabolic biochemistry and drug discovery, with a primary focus on lipid metabolism and enzyme inhibition. His work centers on monoacylglycerol acyltransferase 2 (MGAT2), a key enzyme in dietary fat absorption and metabolic regulation. Ma’s major contribution includes the development of a pioneering cell-based assay for profiling MGAT2 inhibitors, which employs stable isotope-labeled substrates and high-resolution LC/MS to measure diacylglycerol synthesis. This innovative method, detailed in his 2015 paper (11 citations), overcame the limitations of traditional radiolabeled approaches, offering higher throughput and precision for drug screening. By constructing recombinant cell lines from murine secretin tumor cells expressing human MGAT2, Ma provided a physiologically relevant platform for evaluating potential therapeutic compounds targeting obesity and metabolic disorders. His work has been instrumental in advancing the understanding of MGAT2-driven lipid synthesis and its inhibition, with implications for developing treatments for diabetes and dyslipidemia. Ma’s research exemplifies the integration of analytical chemistry and cell biology, making him a notable figure in metabolic disease research.
Research Focus
Key Achievements
Top Papers
- 1