R. Michael Lawrence
Papers
1
Total Citations
11
H-Index
1
About
R. Michael Lawrence is a biochemist specializing in metabolic disease research, with a focus on lipid metabolism and enzyme inhibition. His major contributions center on the development of innovative cellular assays to study monoacylglycerol acyltransferase 2 (MGAT2), a key enzyme in dietary fat absorption and triglyceride synthesis. In his most-cited work (2015, 11 citations), Lawrence pioneered a cell-based assay for profiling MGAT2 inhibitors, replacing traditional low-throughput, radiolabeled methods with a stable isotope-labeled substrate and high-resolution LC/MS. This approach enabled more accurate, scalable screening of potential therapeutic compounds for obesity and metabolic disorders. By constructing recombinant human MGAT2-expressing cell lines from murine enteroendocrine cells, he provided a physiologically relevant platform for drug discovery. Though his citation count reflects a focused, emerging impact, Lawrence’s work represents a critical methodological advance in metabolic pharmacology, bridging cellular biology and analytical chemistry. His assay design has implications for developing targeted therapies against dyslipidemia and type 2 diabetes, marking him as a contributor to precision tools in metabolic research.
Research Focus
Key Achievements
Top Papers
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