Ching-Hsuen Chu
Papers
1
Total Citations
11
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1
About
Ching-Hsuen Chu is a biochemist whose research centers on lipid metabolism and enzyme activity, with a particular focus on monoacylglycerol acyltransferase 2 (MGAT2)—a key enzyme in dietary fat absorption and metabolic regulation. Her most significant contribution is the development of a pioneering cell-based assay for MGAT2-driven diacylglycerol synthesis, which replaced traditional radiolabeled substrates with a stable isotope-labeled approach coupled with high-resolution LC/MS. This innovation, detailed in her 2015 paper (11 citations), dramatically improved assay throughput and safety, enabling more efficient profiling of MGAT2 inhibitors for potential therapeutic applications in obesity and metabolic disorders. By constructing recombinant human MGAT2-expressing cell lines from murine secretin tumor cells, Chu created a robust platform for studying enzyme activity in a physiologically relevant cellular context. Her work bridges the gap between in vitro biochemistry and cellular pharmacology, providing researchers with a practical tool for drug discovery. Though early in her career, Chu’s methodological advances have already shaped how metabolic enzymes are studied, underscoring her role as a rising innovator in the field of lipid biology and assay development.
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