Thassadite Dirami
Papers
1
Total Citations
116
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1
About
Thassadite Dirami is a leading molecular biologist whose research centers on the genetic and cellular mechanisms underlying male infertility, with a particular focus on sperm motility and ion channel regulation. Her most impactful contribution is the discovery that missense mutations in the SLC26A8 gene cause human asthenozoospermia, a condition characterized by reduced sperm motility. In her landmark 2013 study, cited over 116 times, Dr. Dirami demonstrated that SLC26A8 encodes a sperm-specific activator of the CFTR chloride channel, revealing a critical signaling pathway for sperm flagellar function. This work not only provided the first genetic evidence linking SLC26A8 to human infertility but also established a new paradigm for understanding how ion transport defects impair male reproductive health. Her findings have opened avenues for diagnostic screening and potential therapeutic targets in assisted reproduction. Dr. Dirami’s research continues to bridge basic cell biology and clinical genetics, making her a key figure in the study of sperm physiology and the molecular pathology of male infertility.
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