Papers
1
Total Citations
173
H-Index
1
About
T Saxton is a leading figure in neglected tropical disease drug discovery, with a primary focus on Chagas disease—a life-threatening parasitic illness affecting millions. Their most influential work, a 2009 review with 173 citations, critically examines two complementary strategies for developing new treatments: target-based drug discovery and phenotypic screening. At the Sandler Center, University of California, San Francisco, Saxton advanced the field by identifying and validating cytochrome P450 as a promising drug target, laying essential groundwork for novel therapeutic candidates. This research has shaped how scientists approach the challenge of repurposing or designing compounds against *Trypanosoma cruzi*, the parasite responsible for Chagas disease. Saxton’s contributions are particularly notable for bridging fundamental biochemistry with practical drug development, offering a roadmap that has guided subsequent high-impact studies. Their work remains a cornerstone reference for researchers seeking to combat this devastating disease, demonstrating how strategic, mechanism-driven approaches can accelerate progress in resource-limited therapeutic areas.
Research Focus
Key Achievements
Top Papers
- 1Two approaches to discovering and developing new drugs for Chagas disease173 citations · 2009