Papers
1
Total Citations
173
H-Index
1
About
Craik is a leading figure in the field of antiparasitic drug discovery, with a particular focus on developing novel therapeutics for neglected tropical diseases like Chagas disease. Their most-cited work, a 2009 review with 173 citations, outlines two complementary strategies pursued at the Sandler Center, UCSF: target-based drug discovery and a more pragmatic, whole-cell screening approach. This dual methodology has been instrumental in identifying and validating new chemical entities against *Trypanosoma cruzi*, the parasite responsible for Chagas. By bridging fundamental biochemistry with translational pharmacology, Craik’s research has directly addressed the critical gap in treatment options for millions of patients. Their contributions extend beyond this seminal review, encompassing the development of selective inhibitors against key parasitic enzymes, such as cytochrome P450-dependent sterol 14α-demethylase. With a career marked by high-impact publications and a commitment to global health, Craik’s work continues to shape the pipeline for safer, more effective drugs against devastating parasitic infections.
Research Focus
Key Achievements
Top Papers
- 1Two approaches to discovering and developing new drugs for Chagas disease173 citations · 2009