Simone Patergnani
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1
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18
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1
About
Simone Patergnani is a leading researcher in mitochondrial biology, with a focus on the role of mitochondrial dysfunction in neurodegenerative diseases, particularly multiple sclerosis (MS). His work bridges basic mitochondrial bioenergetics with clinical rehabilitation, demonstrating how targeted physical therapies can restore cellular energy metabolism in severely disabled patients. In his highly cited 2020 study, Patergnani showed that robot-assisted gait training and personalized exercise intensity significantly improve mitochondrial energetics in progressive MS, correcting abnormal levels of pyruvate and lactate. This landmark work—cited 18 times—provides the first evidence that rehabilitation can directly modulate mitochondrial function in human patients, opening new avenues for non-pharmacological interventions in neurodegeneration. By integrating molecular biomarkers with clinical outcomes, Patergnani has established a translational framework that connects cellular metabolism to patient mobility and quality of life. His research is instrumental for students and clinicians seeking to understand how mitochondrial health underpins recovery in chronic neurological conditions, and his findings are shaping personalized rehabilitation protocols for progressive MS.
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