Pascal Egloff
Papers
1
Total Citations
39
H-Index
1
About
Pascal Egloff is a structural biologist whose research focuses on membrane protein stabilization and characterization, particularly G protein-coupled receptors (GPCRs). His most cited work, "Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies" (2014, 39 citations), introduces the CHESS (Cysteine-Histidine-Engineered Stability Strategy) method to enhance the detergent stability of the neurotensin receptor NTS1 in its ligand-free state. This contribution is critical for enabling high-resolution structural studies and pharmacological assays of GPCRs, which are notoriously difficult to stabilize outside their native membrane environment. Egloff’s approach directly addresses a key bottleneck in membrane protein research, allowing researchers to investigate receptor dynamics and drug interactions more effectively. His work has been instrumental in advancing the toolkit for GPCR structural biology, with implications for drug discovery targeting neurological and metabolic disorders. By improving the stability of apo-state receptors, Egloff has facilitated more accurate modeling of receptor activation and signaling, earning recognition among peers in the field.
Research Focus
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Top Papers
- 1