Ross A. D. Bathgate

Papers

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About

Ross A. D. Bathgate is a leading figure in peptide hormone research, renowned for his pioneering work on the relaxin and insulin-like peptide families. His major contributions center on elucidating the structure, function, and therapeutic potential of these hormones, particularly relaxin-3 and its receptor, RXFP3. Bathgate’s research has been instrumental in understanding how these peptides regulate neuroendocrine signaling, stress responses, and reproductive physiology. His work has garnered significant impact, with his most cited papers collectively accumulating thousands of citations—including foundational studies on relaxin-3’s role in the brain and RXFP3 pharmacology. Notably, his 2014 paper on improving detergent stability of the NTS1 receptor (39 citations) exemplifies his methodological innovations in structural biology, enabling more accurate pharmacological and structural studies. Bathgate has also contributed to drug discovery efforts targeting relaxin-family receptors for conditions like anxiety, obesity, and fibrosis. His achievements include leadership roles at the Florey Institute of Neuroscience and Mental Health and recognition as a Fellow of the Australian Academy of Science. For students and researchers, Bathgate’s work offers a masterclass in bridging basic peptide biology with translational applications.