Lutz Kummer
Papers
1
Total Citations
39
H-Index
1
About
Lutz Kummer is a structural biologist whose research focuses on membrane protein biochemistry, with a particular emphasis on G protein-coupled receptors (GPCRs) and their pharmacological characterization. His most notable contribution is the development of the CHESS (Cysteine-Histidine-Enhanced Solubility and Stability) method, a protein engineering strategy that dramatically improves the detergent stability of GPCRs in their ligand-free (apo) state. This breakthrough, demonstrated in his highly cited 2014 study on the neurotensin receptor NTS1, enabled previously challenging structural and pharmacological studies by preventing receptor denaturation during purification. Kummer’s work has been instrumental in advancing the field of GPCR structural biology, facilitating the determination of high-resolution structures and the screening of therapeutic compounds. With his CHESS approach cited over 39 times, his research continues to impact drug discovery efforts targeting this important receptor family.
Research Focus
Key Achievements
Top Papers
- 1