Olav Spigset
Papers
5
Total Citations
163
H-Index
4
About
Olav Spigset is a prominent Norwegian clinical pharmacologist and researcher whose work centers on therapeutic drug monitoring, analytical toxicology, and the pharmacokinetics of clinically significant drug classes. His research has made substantial contributions to the development and validation of advanced chromatographic and mass spectrometric methods for quantifying drugs in biological matrices, enabling more precise and individualized patient care. Spigset's most impactful work includes the development of UHPLC-MS/MS methods for quantifying direct oral anticoagulants such as apixaban, dabigatran, edoxaban, and rivaroxaban in human serum — a study that has garnered 50 citations and addresses real clinical needs in anticoagulation management. His equally influential research on UPLC-MS/MS screening for drugs of abuse in urine (46 citations) and UHPLC-QTOF-MS detection of synthetic cannabinoid metabolites (38 citations) reflects his commitment to forensic and clinical toxicology. His contributions extend to antihypertensive drug quantification and cutting-edge chiral separation techniques for methadone enantiomers using supercritical fluid chromatography. Across these areas, Spigset's methodology-driven approach has provided laboratories worldwide with reliable, validated tools that bridge analytical chemistry and clinical practice.
Research Focus
Key Achievements
Top Papers
- 1
- 2
- 3
- 4Quantification of 21 antihypertensive drugs in serum using UHPLC-MS/MS25 citations · 2018
- 5