Nicolas Tarbouriech

Centre National de la Recherche Scientifique

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About

Nicolas Tarbouriech is a structural biologist whose work has fundamentally advanced our understanding of herpesviruses, particularly the Epstein–Barr virus (EBV). His research integrates structural genomics, X-ray crystallography, and virology to decode the molecular machinery of viral replication and pathogenesis. Tarbouriech led a landmark structural genomics project on EBV, systematically annotating its 86-protein genome and selecting 23 open reading frames for expression and structural determination. This foundational work, published in 2006 and cited over 44 times, provided the first comprehensive structural framework for EBV proteins, enabling targeted studies of viral assembly, immune evasion, and oncogenesis. Beyond EBV, his contributions extend to other herpesviruses, where his structures have illuminated mechanisms of capsid maturation and DNA packaging. Tarbouriech’s impact is reflected in his sustained citation record and his role in bridging genomics with atomic-level biology. His work remains essential for researchers developing antiviral therapies and vaccines, offering a molecular blueprint for combating herpesvirus-associated diseases, from infectious mononucleosis to lymphomas and carcinomas.