Marlyse Buisson

Centre National de la Recherche Scientifique

Papers

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About

Marlyse Buisson is a structural biologist whose work has significantly advanced our understanding of the Epstein–Barr virus (EBV), a herpesvirus linked to infectious mononucleosis, carcinomas, and immunoproliferative diseases. Her key research areas include structural genomics, viral protein characterization, and the molecular mechanisms underlying EBV pathogenesis. Her most notable contribution is the landmark 2006 study on the structural genomics of EBV, which has garnered 44 citations. In this work, Buisson and her team updated the annotation of the EBV genome, selecting 23 open reading frames for expression and structural analysis—a foundational effort that has guided subsequent research into viral protein function and potential therapeutic targets. By systematically mapping the three-dimensional structures of EBV proteins, she has provided critical insights into how the virus hijacks host cellular machinery, paving the way for novel antiviral strategies. Buisson’s meticulous approach to structural genomics has not only illuminated the complex biology of EBV but also established a methodological framework for studying other large DNA viruses. Her work remains a vital resource for virologists and structural biologists seeking to combat herpesvirus-associated diseases.