Michelle V Simons

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About

Michelle V Simons is a translational researcher at the forefront of non-invasive cardiovascular interventions, specializing in the application of robot-assisted high-intensity focused ultrasound (HIFU) for the treatment of peripheral artery disease (PAD). Her work bridges biomedical engineering and clinical medicine, with a primary focus on developing safer, less invasive alternatives to traditional revascularization methods for atherosclerotic plaque management. Simons’ major contributions include pioneering preclinical and clinical feasibility studies that demonstrate the safety and efficacy of arterial wall targeting using dual-mode ultrasound arrays (DMUA), which enable simultaneous imaging and thermal ablation. Her 2020 preclinical study (21 citations) established foundational evidence for this approach, while her 2022 pilot study protocol (10 citations) outlines a rigorous pathway for translating this technology into human trials. By addressing the critical limitation of long-term patency in current PAD treatments, Simons’ research holds promise for reducing complications and improving outcomes for millions of patients. Her work is particularly notable for integrating robotic precision with non-invasive energy delivery, a paradigm shift in vascular therapy. With a growing citation footprint, Simons is emerging as a key innovator in interventional ultrasound and a bridge between engineering innovation and clinical application.