Papers
5
Total Citations
1,035
H-Index
5
About
Mark Stitt is a pioneering plant systems biologist whose research centers on the dynamic regulation of central carbon and nitrogen metabolism. His major contributions lie in developing high-throughput, robotized platforms to measure enzyme activities, bridging the gap between transcriptomics and metabolomics. His landmark 2004 paper (547 citations) introduced a robotic platform for assaying 23 enzymes in *Arabidopsis*, revealing how enzyme activities and transcripts change during diurnal cycles and prolonged darkness. This work was foundational for understanding metabolic regulation at the systems level. Stitt further demonstrated the power of this approach in a 2007 study (300 citations), which tracked the temporal responses of transcripts, enzyme activities, and metabolites after sucrose resupply to carbon-starved seedlings. Beyond *Arabidopsis*, he applied these techniques to crop species, mapping quantitative trait loci for enzyme activities in maize (65 citations) and tomato (38 citations) to link metabolism with yield and nitrogen use efficiency. His influential 2013 perspective (85 citations) critically addressed the role of enzyme activity measurements in systems biology. Stitt’s work has fundamentally advanced our ability to quantify and model plant metabolic networks, providing essential tools for engineering improved crop performance.
Research Focus
Key Achievements
Top Papers
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- 3Why measure enzyme activities in the era of systems biology?85 citations · 2013
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