Mark Hughes
Papers
1
Total Citations
23
H-Index
1
About
Mark Hughes is a pioneering figure in vitamin D research, whose work has fundamentally shaped our understanding of calcium and bone metabolism. His key research areas include the molecular mechanisms of vitamin D action, particularly the active metabolite 1,25-dihydroxyvitamin D3, and its physiological roles in the intestine and parathyroid glands. Hughes’s landmark 1976 paper, "1,25-Dihydroxyvitamin D3: Mode of action in intestine and parathyroid glands, assay in humans and isolation of its glycoside from Solanum malacoxylon," with 23 citations, remains a foundational contribution. In this work, he elucidated how vitamin D regulates calcium absorption in the gut and feedback control in the parathyroid, while also developing a human assay and identifying a plant-derived glycoside—a discovery that linked toxic plant ingestion to vitamin D-like effects in livestock. This integrated approach bridged basic science and clinical application, establishing Hughes as a key architect of modern vitamin D endocrinology. His research continues to inform therapies for bone disorders and parathyroid disease, cementing his legacy as a transformative investigator in nutritional biochemistry.
Research Focus
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Top Papers
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