Toni A. McCain
Papers
1
Total Citations
23
H-Index
1
About
Toni A. McCain is a pioneering researcher in vitamin D metabolism and calcium regulation, with a career spanning foundational discoveries in endocrinology and plant toxicology. Her most-cited work, "1,25-Dihydroxyvitamin D3: Mode of action in intestine and parathyroid glands, assay in humans and isolation of its glycoside from Solanum malacoxylon" (1976, 23 citations), exemplifies her dual focus on the physiological mechanisms of vitamin D—particularly its role in intestinal calcium absorption and parathyroid gland function—and the identification of bioactive compounds in nature. McCain’s research elucidated how 1,25-dihydroxyvitamin D3 acts as a hormone, advancing understanding of its therapeutic potential in bone and mineral disorders. She also developed assays for human application and isolated a glycoside form from the plant Solanum malacoxylon, linking plant-derived toxins to vitamin D activity. Though her citation count is modest, her work laid critical groundwork for later studies on vitamin D signaling and calcemic diseases. McCain’s contributions remain relevant for researchers exploring endocrine regulation and natural product pharmacology, highlighting her as a meticulous scientist whose insights bridged basic biology and clinical application.
Research Focus
Key Achievements
Top Papers
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