Mariana Lopes dos Santos
Papers
1
Total Citations
5
H-Index
1
About
Mariana Lopes dos Santos is a biotechnologist whose work bridges therapeutic protein production and biosimilar development. Her research centers on mammalian cell engineering for monoclonal antibody expression, with a particular focus on optimizing Chinese hamster ovary (CHO) cell lines for biopharmaceutical manufacturing. Her most cited study, "A new CHO-derived cell line expressing anti-TNFα monoclonal antibody with biosimilar potential" (2018), demonstrates her contribution to the growing field of biosimilars—cost-effective alternatives to biologic drugs. In this work, she successfully engineered a stable CHO cell line capable of producing an anti-TNFα antibody, a critical therapeutic for autoimmune diseases like rheumatoid arthritis. Though her citation count remains modest, her research addresses a pressing need in global healthcare: expanding access to biologic treatments through biosimilar innovation. Her work is notable for its translational potential, directly impacting the development pipeline for affordable immunotherapies. For students and researchers in biotechnology, dos Santos exemplifies how targeted cell engineering can democratize access to life-saving biologics, making her a promising figure in the next generation of bioprocess scientists.
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Top Papers
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