Carla Ploeger Mansueli

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About

Carla Ploeger Mansueli is a biotechnology researcher whose work centers on the development and characterization of therapeutic monoclonal antibodies, with a particular focus on biosimilar production. Her most cited paper, "A new CHO (Chinese hamster ovary)-derived cell line expressing anti-TNFα monoclonal antibody with biosimilar potential" (2018), has garnered 5 citations and represents a significant contribution to the field of biopharmaceutical manufacturing. In this study, Mansueli engineered a stable Chinese hamster ovary (CHO) cell line capable of producing an anti-TNFα antibody, demonstrating its potential as a cost-effective biosimilar for treating autoimmune diseases such as rheumatoid arthritis. This work addresses critical challenges in biologics production, including cell line stability and product quality. While her citation count reflects an emerging career, her research is foundational for advancing accessible biologic therapies. Mansueli's contributions highlight the intersection of cell engineering and therapeutic development, offering a pathway to more affordable treatments. Her work continues to inspire innovations in biosimilar manufacturing, positioning her as a promising figure in the biotechnology landscape.