M. V. Korsakov

About

M. V. Korsakov is a pioneering radiochemist whose work has significantly advanced the field of positron emission tomography (PET) tracer development. His research focuses on the asymmetric synthesis of carbon-11 labeled amino acids and the automation of radiochemical processes, enabling the production of critical imaging agents for neurological and oncological studies. Korsakov’s most notable contribution is the asymmetric synthesis of L-[β-11C]-3,4-dihydroxyphenylalanine (L-[β-11C]-DOPA) via a chiral Ni(II) complex, a landmark achievement that provided a high-yield, enantioselective route to this essential PET tracer for dopamine system imaging. This work, cited 5 times, remains a foundational reference in radiochemistry. Additionally, his development of a robotic synthesis system for [1-carbon-11]acetic acid (4 citations) demonstrated early innovation in automated radiochemistry, streamlining the production of short-lived isotopes for clinical use. Korsakov’s contributions have enabled more efficient and accessible PET tracer synthesis, impacting both basic neuroscience research and clinical diagnostics. His dedication to method development and automation continues to inspire radiochemists seeking to bridge chemistry and medicine.

Research Focus

Key Achievements

Top Papers

1. 1
   Asymmetric Synthesis of L-[β-11C]-3,4-Dihydroxyphenylalanine via the Chiral Ni(II) Complex of the Schiff Base Derived from (S)-o-N-(N'-Benzylprolyl)aminobenzophenone and Glycine (Ni-BPB-Gly)

   5 citations · 2002
2. 2
   Robotic synthesis of [1-carbon-11]acetic acid

   4 citations · 1992

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