Olga Kuznetsova

About

Olga Kuznetsova is a pioneering radiochemist whose work has advanced the synthesis of radiolabeled amino acids for positron emission tomography (PET) imaging. Her research focuses on developing asymmetric synthetic methods to produce carbon-11 and fluorine-18 labeled compounds, which are critical for studying neurological disorders and cancer metabolism. Kuznetsova’s most notable contribution is the asymmetric synthesis of L-[β-¹¹C]-3,4-dihydroxyphenylalanine (L-DOPA) using a chiral Ni(II) complex, a breakthrough that enabled the production of this key PET radiotracer with high enantiomeric purity. This work, published in 2002, has garnered 5 citations and remains foundational for neuroimaging studies of dopamine function. She also pioneered the robotic synthesis of [1-¹¹C]acetic acid (1992, 4 citations), demonstrating early adoption of automation to improve reproducibility and safety in radiochemistry. Additionally, her preparation of [¹⁸F]fluorobenzyl bromides (2002, 3 citations) provided a versatile building block for synthesizing fluorinated α-amino acids, expanding the toolkit for PET tracer development. Kuznetsova’s contributions, though modest in citation counts, reflect meticulous methodology and enduring relevance in the niche field of radiopharmaceutical chemistry.

Research Focus

Key Achievements

Top Papers

1. 1
   Asymmetric Synthesis of L-[β-11C]-3,4-Dihydroxyphenylalanine via the Chiral Ni(II) Complex of the Schiff Base Derived from (S)-o-N-(N'-Benzylprolyl)aminobenzophenone and Glycine (Ni-BPB-Gly)

   5 citations · 2002
2. 2
   Robotic synthesis of [1-carbon-11]acetic acid

   4 citations · 1992
3. 3
   Prepatation of [18F]Fluorobenzyl Bromides for Their Use in Asymmetric Synthesis of Fluorinated α-Amino Acids, Radiotracers for Positron Emission Tomography

   3 citations · 2002

Key Collaborators

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