N. A. Gomzina

About

N. A. Gomzina is a leading radiochemist whose work has been instrumental in advancing the synthesis of radiotracers for Positron Emission Tomography (PET), particularly for oncology and neurology. Her research focuses on the development of efficient, automated methods for producing fluorine-18 labeled compounds, which are critical for non-invasive diagnostic imaging. Her most impactful contribution is the optimization of the automated synthesis of 2-[¹⁸F]Fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) involving base hydrolysis, a foundational paper with 27 citations that has helped streamline the production of the world’s most widely used PET tracer. Gomzina also pioneered the use of 2-[¹⁸F]fluoroethyl bromide as a labeled reagent for selective O-[¹⁸F]fluoroethylation, demonstrated in the synthesis of O-(2′-[¹⁸F]fluoroethyl)-L-tyrosine, a radiotracer for brain tumor diagnostics. Her work on preparing [¹⁸F]fluorobenzyl bromides for asymmetric synthesis of fluorinated α-amino acids further showcases her expertise in creating complex, high-specific-activity probes. Through these innovations, Gomzina has directly enabled more accessible and precise PET imaging, making her a key figure in the field of radiopharmaceutical chemistry.

Research Focus

Key Achievements

Top Papers

1. 1
   Optimization of Automated Synthesis of 2-[18F]Fluoro-2-deoxy-D-glucose Involving Base Hydrolysis

   27 citations · 2002
2. 2
   Use of 2-[18F]fluoroethyl bromide in synthesis of O-(2′-[18F]fluoroethyl)-L-tyrosine, a radiotracer for PET diagnostics of brain tumors

   8 citations · 2007
3. 3
   Prepatation of [18F]Fluorobenzyl Bromides for Their Use in Asymmetric Synthesis of Fluorinated α-Amino Acids, Radiotracers for Positron Emission Tomography

   3 citations · 2002

Key Collaborators

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