Lisa M. Kopcho
Papers
1
Total Citations
11
H-Index
1
About
Lisa M. Kopcho is a distinguished researcher in metabolic disease pharmacology, with a specialized focus on lipid metabolism and enzyme inhibition. Her key research areas include monoacylglycerol acyltransferase 2 (MGAT2) biology and the development of innovative cell-based assays for drug discovery. Her most notable contribution is the development of a groundbreaking cell-based assay for MGAT2-driven diacylglycerol synthesis, which replaced traditional low-throughput, radiolabeled methods with a sophisticated stable isotope-labeled substrate approach coupled with high-resolution LC/MS. This work, published in 2015, has garnered 11 citations and represents a significant methodological advancement in the field. By constructing human MGAT2-expressing recombinant cell lines from murine secretin tumor cells, Kopcho enabled more physiologically relevant profiling of inhibitors, bridging the gap between biochemical assays and in vivo systems. Her work has been instrumental in advancing the understanding of MGAT2's role in dietary fat absorption and metabolic disorders, providing researchers with a powerful tool for developing potential therapeutics for obesity and related metabolic conditions.
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