Larissa M. Podust
Papers
1
Total Citations
37
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1
About
Dr. Larissa M. Podust is a leading structural biologist whose research centers on the cytochrome P450 enzymes of *Mycobacterium tuberculosis*, with a particular focus on their role in pathogen survival and their potential as novel drug targets. Her major contributions lie in elucidating the structure and function of these essential mycobacterial P450s, demonstrating their susceptibility to inhibition by azole drugs—a finding with direct therapeutic implications. Her seminal 2009 work on the interaction of *M. tuberculosis* CYP130 with heterocyclic arylamines, cited 37 times, provided critical structural insights into how these enzymes bind small-molecule inhibitors, paving the way for rational drug design against tuberculosis. By bridging structural biology and pharmacology, Dr. Podust has established a foundational framework for developing next-generation antimycobacterial agents that target P450 enzymes, a strategy that holds promise for overcoming drug resistance. Her research continues to inspire efforts to repurpose and optimize azole-based compounds for tuberculosis treatment, marking her as a key figure in the fight against this global health threat.
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