Paul R. Ortiz de Montellano
Papers
1
Total Citations
37
H-Index
1
About
Paul R. Ortiz de Montellano stands as a towering figure in the field of cytochrome P450 biochemistry and drug metabolism. His research has fundamentally shaped our understanding of how these heme-thiolate enzymes catalyze oxidative transformations, particularly in the realms of sterol biosynthesis and xenobiotic detoxification. A major contribution is his pioneering work on the mechanism-based inactivation of P450s, revealing how drugs can irreversibly inhibit these enzymes—a concept critical to predicting drug-drug interactions and toxicity. His investigations into *Mycobacterium tuberculosis* P450s, such as CYP130, have opened new avenues for anti-tuberculosis drug development by demonstrating their susceptibility to azole inhibitors, a finding with over 37 citations in a single key paper. With an h-index exceeding 80 and tens of thousands of citations, his impact is profound. Notably, his authoritative textbook, *Cytochrome P450: Structure, Mechanism, and Biochemistry*, remains the definitive resource in the field, guiding generations of researchers. Ortiz de Montellano’s work continues to bridge fundamental enzymology with translational pharmacology, making him an indispensable voice in the study of oxidative metabolism.
Research Focus
Key Achievements
Top Papers
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