Kaylene J. Simpson
Papers
4
Total Citations
84
H-Index
3
About
Kaylene J. Simpson is a pioneering translational researcher whose work bridges functional genomics, high-throughput drug screening, and 3D cancer modeling to accelerate the discovery of novel therapeutics. Her primary research areas include prostate cancer, ovarian cancer, and infectious disease, with a particular focus on developing robust preclinical platforms that better recapitulate human disease. Simpson’s major contributions lie in the creation and validation of high-content imaging assays for 3D organoid cultures, enabling the screening of drug libraries against patient-derived xenograft models—a critical step for identifying treatments for cancers with limited preclinical tools, such as advanced prostate cancer. Her 2021 paper on high-throughput drug screening in 3D prostate cancer organoids has garnered 67 citations, reflecting its impact on the field. More recently, her 2024 work on low-grade serous ovarian carcinoma (13 citations) addresses a rare cancer subtype often excluded from clinical trials, highlighting her commitment to understudied malignancies. Notably, Simpson has also applied her expertise to virology, leading a genome-wide microRNA screen to uncover host factors modulating SARS-CoV-2 infection. Through her innovative assay development and dedication to translating functional genomics into actionable therapies, Simpson continues to shape the future of precision oncology and antiviral drug discovery.
Research Focus
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Top Papers
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