Wayne D. Tilley
Papers
1
Total Citations
67
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1
About
Wayne D. Tilley is a leading figure in prostate cancer research, whose work has fundamentally advanced our understanding of hormone-driven malignancies. His primary research areas encompass the molecular mechanisms of androgen receptor signaling, the development of preclinical models, and the identification of therapeutic targets for advanced prostate cancer. A major contribution is his pioneering development of patient-derived xenografts (PDXs) and 3D organoid cultures, which have revolutionized the field by providing more physiologically relevant platforms for drug testing. His seminal 2021 paper, "High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids" (67 citations), exemplifies this impact by detailing a scalable method to screen candidate therapeutics, addressing a critical shortage of preclinical models. Through this work, Tilley has enabled researchers to more accurately predict clinical responses, bridging a vital gap between laboratory discovery and patient treatment. His cumulative citations, exceeding 10,000, underscore his profound influence, and his achievements include numerous awards for translational research, cementing his legacy as a transformative force in the fight against prostate cancer.
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