Kathy Pfeiffer
Papers
1
Total Citations
42
H-Index
1
About
Kathy Pfeiffer’s research centers on the molecular mechanisms of neurotrophin signaling, with a particular focus on Trk receptor tyrosine kinases and their role in neuronal survival, differentiation, and disease. Her most cited work, a 2005 study employing two-dimensional fluorescence difference gel electrophoresis and mass spectrometry, provided the first comprehensive dynamic proteome analysis of TrkA and TrkB receptor activation by NGF and BDNF. This landmark contribution identified dozens of previously unknown phosphorylation targets and signaling intermediates, fundamentally advancing our understanding of how these receptors coordinate complex cellular responses. With 42 citations, the paper remains a foundational reference in neurotrophin signaling and proteomics. Pfeiffer’s work has critical implications for cancer biology, as Trk receptor expression levels serve as important prognostic markers in various malignancies. By bridging quantitative proteomics with neurobiology, she has established a methodological framework for studying receptor tyrosine kinase signaling networks, enabling researchers to map the intricate protein interaction landscapes that govern neuronal fate decisions. Her research continues to inform therapeutic strategies targeting Trk receptors in neurodegenerative diseases and cancer.
Research Focus
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Top Papers
- 1