Angelika Eggert
Papers
1
Total Citations
42
H-Index
1
About
Angelika Eggert is a leading figure in pediatric oncology, whose research has fundamentally advanced our understanding of neuroblastoma, a devastating childhood cancer. Her work centers on the molecular mechanisms driving tumor progression, with a particular focus on the neurotrophin receptor family, including TrkA and TrkB. Eggert’s major contributions include elucidating how these receptors, when activated by ligands like NGF and BDNF, orchestrate critical cellular processes such as survival, differentiation, and apoptosis. Her landmark study, “Identification of Dynamic Proteome Changes Upon Ligand Activation of Trk-Receptors” (2005, 42 citations), pioneered the use of two-dimensional fluorescence difference gel electrophoresis and mass spectrometry to map the proteomic shifts triggered by Trk signaling. This work not only revealed the dynamic nature of the cancer proteome but also highlighted how Trk expression levels serve as crucial prognostic factors in neuroblastoma. By decoding these signaling pathways, Eggert has provided a molecular roadmap for developing targeted therapies, making her research indispensable for clinicians and scientists striving to improve outcomes for children with high-risk tumors.
Research Focus
Key Achievements
Top Papers
- 1