Jesus Shrestha

Papers

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About

Jesus Shrestha is a pioneering researcher in biopreservation and stem cell manufacturing, with a primary focus on advancing cryopreservation technologies for cell-based therapies. His most cited work, "Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer" (2022, 6 citations), addresses a critical bottleneck in industrial-scale stem cell production: the efficient and gentle addition of cryoprotecting agents (CPAs). Shrestha's major contribution lies in developing a 3D micromixer-based system that enables rapid, continuous CPA loading, overcoming the limitations of conventional manual or robotic-arm methods, which struggle with scalability and cell viability. This innovation directly tackles challenges in automating the final cryopreservation step before cryostorage, a key hurdle for commercializing cell therapies. His work has the potential to significantly improve throughput and consistency in stem cell manufacturing, impacting fields from regenerative medicine to drug discovery. By focusing on process intensification and microfluidics, Shrestha is helping to bridge the gap between laboratory research and clinical-scale production, making him a notable figure in bioprocess engineering.