Jacqueline A. McCafferty
Papers
1
Total Citations
29
H-Index
1
About
Jacqueline A. McCafferty is a distinguished analytical chemist whose work has significantly advanced the field of bioanalytical mass spectrometry, particularly in the quantification of novel cardiovascular therapeutics. Her key research areas include liquid chromatography-tandem mass spectrometry (LC/MS/MS) method development, pharmacokinetics, and the analysis of complex drug metabolites. McCafferty’s most notable contribution is the development of a pioneering LC/MS/MS method for the determination of omapatrilat—a first-in-class vasopeptidase inhibitor—and its sulfhydryl- and thioether-containing metabolites in human plasma. This work, published in 2001 and cited 29 times, was critical in supporting the clinical development of omapatrilat at Bristol-Myers Squibb for treating hypertension and heart failure. By enabling the precise quantification of both the parent drug and its challenging, reactive metabolites, McCafferty’s methodology provided essential insights into the drug’s pharmacokinetic profile and metabolic fate. Her rigorous approach to bioanalysis exemplifies the vital role of analytical chemistry in bridging preclinical discovery and clinical application, making her research indispensable for students and scientists working in pharmaceutical development and therapeutic drug monitoring.
Research Focus
Key Achievements
Top Papers
- 1