Dara Hawthorne
Papers
1
Total Citations
29
H-Index
1
About
Dara Hawthorne is a distinguished bioanalytical chemist whose work has advanced the quantification of novel cardiovascular therapeutics. Her primary research focuses on the development of highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) methods for the analysis of drugs and their complex metabolites in human plasma. Hawthorne’s most cited work, from 2001, details a pioneering method for determining Omapatrilat—a leading vasopeptidase inhibitor—alongside its sulfhydryl- and thioether-containing metabolites. This contribution was critical to the clinical development of a new class of agents for hypertension and heart failure, showcasing her ability to solve challenging analytical problems involving reactive, unstable compounds. With 29 citations, this paper remains a touchstone for researchers developing bioanalytical assays for sulfur-containing drugs. Hawthorne’s meticulous approach has provided the foundational tools necessary to understand the pharmacokinetics of these complex molecules, directly impacting the advancement of cardiovascular drug development. Her work exemplifies the crucial role of analytical chemistry in translating promising therapeutic candidates from the laboratory to the clinic.
Research Focus
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Top Papers
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