Mohammed Jemal

About

Mohammed Jemal is a pioneering bioanalytical chemist whose career has centered on the development and optimization of sample preparation techniques for biological fluids, particularly in the context of pharmaceutical drug analysis using liquid chromatography-tandem mass spectrometry (LC/MS/MS). Working extensively at Bristol-Myers Squibb Pharmaceutical Research Institute, Jemal has made landmark contributions to streamlining the analytical workflows that underpin drug development and regulated bioanalysis. His most celebrated work, a 1999 study comparing manual and automated plasma sample purification methods, has garnered 79 citations and remains a key reference for bioanalytical scientists choosing extraction strategies. Jemal's research on omapatrilat — a novel vasopeptidase inhibitor for hypertension and heart failure — demonstrated his ability to apply sophisticated LC/MS/MS techniques to chemically complex, clinically relevant compounds. Further advancing laboratory efficiency, he developed innovative automation tools, including a user-friendly robotic sample preparation program and cap-piercing direct sampling systems, reducing human error and accelerating regulated bioanalysis workflows. Across his career, Jemal has consistently bridged technical innovation with practical application, helping modernize the infrastructure of pharmaceutical bioanalysis and earning lasting recognition within the field.

Research Focus

Key Achievements

Top Papers

1. 1
   Comparison of plasma sample purification by manual liquid–liquid extraction, automated 96-well liquid–liquid extraction and automated 96-well solid-phase extraction for analysis by high-performance liquid chromatography with tandem mass spectrometry

   79 citations · 1999
2. 2
   LC/MS/MS Determination of Omapatrilat, a Sulfhydryl-Containing Vasopeptidase Inhibitor, and Its Sulfhydryl- and Thioether-Containing Metabolites in Human Plasma

   29 citations · 2001
3. 3
   A User-Friendly Robotic Sample Preparation Program for Fully Automated Biological Sample Pipetting and Dilution to Benefit the Regulated Bioanalysis

   23 citations · 2012
4. 4
   An automated method of sample preparation of biofluids using pierceable caps to eliminate the uncapping of the sample tubes during sample transfer

   23 citations · 2000
5. 5
   A simplified and completely automated workflow for regulated LC–MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction

   7 citations · 2013

Key Collaborators

Contact & Links