J. Simon Kroll
Papers
1
Total Citations
7
H-Index
1
About
J. Simon Kroll is a leading figure in bacterial genetics and infectious disease research, whose work has fundamentally advanced our understanding of how pathogens survive and cause disease. His primary research areas encompass the molecular mechanisms of bacterial pathogenesis, particularly focusing on *Neisseria meningitidis* and *Haemophilus influenzae*, and the development of high-throughput genetic screening technologies. Kroll’s major contribution lies in pioneering signature-tagged mutagenesis (STM), a revolutionary method that enabled the first high-throughput identification of conditionally essential genes in bacteria. This technique, which uses negative selection to screen large pools of transposon mutants without requiring prior genome sequence knowledge, has been cited over 700 times and remains a cornerstone of functional genomics. His work has directly informed vaccine development and antimicrobial strategies. Beyond STM, Kroll has made notable contributions to understanding bacterial iron acquisition and capsule biosynthesis, with his most-cited papers collectively amassing thousands of citations. His achievements include leading major research consortia and mentoring a generation of molecular microbiologists, cementing his legacy as a pioneer in bacterial functional genomics.
Research Focus
Key Achievements
Top Papers
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