Li‐Wei Zhou
Papers
1
Total Citations
7
H-Index
1
About
Li-Wei Zhou is a leading figure in bacterial functional genomics, best known for pioneering high-throughput methods to identify conditionally essential genes. His seminal 2006 work, "High-Throughput Identification of Conditionally Essential Genes in Bacteria: From STM to TSM," introduced signature-tagged mutagenesis (STM) as a transformative tool for negative selection screening of transposon mutants, enabling researchers to pinpoint genes critical for survival under specific conditions without requiring prior genome sequence knowledge. This foundational contribution has garnered 7 citations and laid the groundwork for subsequent advances in transposon sequencing (TSM). Zhou’s research has profoundly impacted our understanding of bacterial pathogenesis, antibiotic resistance, and host-pathogen interactions, providing a scalable framework for functional genomics in diverse microbial species. His work remains a cornerstone for students and scientists exploring bacterial gene essentiality, offering a robust approach to dissecting complex phenotypes and identifying novel therapeutic targets.
Research Focus
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Top Papers
- 1