David Maltby
Papers
1
Total Citations
38
H-Index
1
About
David Maltby is a pioneering figure in the application of mass spectrometry to structural biology, with a career-long focus on developing and refining high-throughput proteomic techniques. His most cited work, a 2002 study on the nuclear pore complex of *Saccharomyces cerevisiae*, exemplifies his major contribution: the use of matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF) to systematically identify protein-protein interactions in complex cellular machinery. This research, which has garnered 38 citations, helped establish mass spectrometry as the technology of choice for detailed protein identification in complex mixtures, moving beyond traditional electrophoretic methods. Maltby’s expertise lies in the elegant integration of proteolytic digestion, unseparated digest analysis, and database searching, turning these standard methods into a powerful, cohesive pipeline. His work has been instrumental in advancing our understanding of the nuclear pore complex’s architecture, providing a foundational toolkit for subsequent studies in cell biology and proteomics. For students and researchers, Maltby’s legacy is a testament to how methodological innovation can unlock new dimensions of biological discovery.
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Top Papers
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