Daryl L. Fernandes

About

Daryl L. Fernandes is a leading figure in the field of glycomics, with a research focus on developing high-throughput analytical technologies for the structural characterization of glycoproteins. His work is pivotal in two major areas: the quality control and development of biopharmaceuticals, and the discovery of glycan-based biomarkers for human disease. Fernandes has been instrumental in advancing automation for glycosylation analysis, most notably through the application of MALDI-TOF-MS and permethylation techniques, enabling more efficient monitoring of biologic drugs throughout their lifecycle. His highly cited 2014 review on high-throughput glycomics (83 citations) and his 2016 paper on automated permethylation (78 citations) underscore his impact on the field. Additionally, his research on the robustness of serum N-glycan profiling methods has helped standardize pre-analytical variables, ensuring that biomarker discovery is not confounded by sample handling. Through these contributions, Fernandes has helped bridge the gap between fundamental glycomics and practical, regulatory-compliant applications in the pharmaceutical and diagnostic industries.

Research Focus

Key Achievements

Top Papers

1. 1
   High-Throughput Analysis and Automation for Glycomics Studies

   83 citations · 2014
2. 2
   Automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS

   78 citations · 2016
3. 3
   Changes to Serum Sample Tube and Processing Methodology Does Not Cause Inter-Individual Variation in Automated Whole Serum N-Glycan Profiling in Health and Disease

   22 citations · 2015

Key Collaborators

Contact & Links