Corbin W. Whitwell
Papers
1
Total Citations
41
H-Index
1
About
Corbin W. Whitwell has made significant contributions to the field of quantitative proteomics, with a particular focus on the development and application of advanced mass spectrometry and gel electrophoresis techniques. His most cited work, "Multivariable Difference Gel Electrophoresis and Mass Spectrometry" (2006, 41 citations), introduced a powerful methodological framework for investigating complex proteome changes. In this landmark study, Whitwell employed multivariable DIGE/MS to systematically analyze proteins altered in expression and post-translational modification following TGF-β receptor activation in MCF10A mammary epithelial cells overexpressing the HER2/Neu oncogene. This work demonstrated an innovative approach to simultaneously tracking multiple dimensions of proteomic change, providing deeper insights into oncogenic signaling pathways. His research has been instrumental in advancing our understanding of how post-translational modifications and protein expression changes coordinate in response to growth factor signaling. Whitwell's methodological contributions continue to influence proteomics researchers studying cancer biology, particularly those investigating the complex interplay between TGF-β signaling and HER2-driven oncogenesis.
Research Focus
Key Achievements
Top Papers
- 1Multivariable Difference Gel Electrophoresis and Mass Spectrometry41 citations · 2006