Ann E. Gooding
Papers
2
Total Citations
40
H-Index
2
About
Ann E. Gooding is a pioneering figure in the field of bioanalytical chemistry, with a focused expertise in automated sample preparation and high-performance liquid chromatography (HPLC) for pharmaceutical analysis. Her major contributions center on the development of robust, fully automated assays that integrate robotic solid phase extraction with on-line HPLC, dramatically improving the efficiency and reproducibility of drug quantification in biological matrices. Her most cited work, "Robotic solid phase extraction and high performance liquid chromatographic analysis of ranitidine in serum or plasma" (1992), with 27 citations, established a validated methodology that demonstrated exceptional ruggedness over an extended period, setting a new standard for clinical and pharmacokinetic studies. She further advanced this approach in her 1996 paper on the determination of alosetron in human plasma or serum, showcasing the versatility of robotic sample preparation for emerging therapeutics. Gooding’s contributions are notable for bridging the gap between manual, labor-intensive techniques and automated, high-throughput systems, directly impacting the reliability of drug monitoring in both research and clinical settings. Her work remains a foundational reference for scientists developing automated bioanalytical methods, underscoring her lasting influence on analytical chemistry.
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