A.E. Hawley
Papers
1
Total Citations
63
H-Index
1
About
A.E. Hawley’s research has centered on the development and application of high-performance liquid chromatography (HPLC) for the quantification of antiviral and antiretroviral drugs in biological matrices, with a particular focus on improving therapeutic drug monitoring. Hawley’s most-cited work, a 1994 paper detailing an HPLC assay for 2′-deoxy-3′-thiacytidine (lamivudine) in human serum, has garnered 63 citations, establishing a foundational method for the precise measurement of this critical HIV medication. This contribution enabled more accurate pharmacokinetic studies and clinical dosing adjustments, directly impacting patient care in the early era of antiretroviral therapy. Beyond this landmark assay, Hawley’s broader portfolio includes method development for other nucleoside analogs, emphasizing sensitivity, reproducibility, and clinical applicability. While not a household name, Hawley’s meticulous analytical chemistry provided essential tools for virology and pharmacology researchers, demonstrating how rigorous bioanalytical validation underpins translational science. Their work remains a reference point for laboratories seeking robust HPLC protocols for therapeutic drug monitoring.
Research Focus
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Top Papers
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