Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor

Abstract

: High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher intensities and longer durations, resulting in a corresponding increase in circulating brain-derived neurotrophic factor (BDNF). Results: Eleven individuals >6-mo poststroke completed a two-session, pilot randomized crossover trial (NCT05138016). Maximum training speed (Δ: 0.07±0.03 m/s), duration (Δ: 2.07±0.88 min), and intensity (VO2 peak, Δ: 1.75±0.60 ml-O2/kg/min) significantly increased (p<0.05) during exosuit-augmented training compared to no-exosuit training. Post-session increases in BDNF (Δ: 5.96±2.27 ng/ml, p=0.03) were observed only after exosuit-augmented training. Biomechanical changes were not observed after exosuit-augmented training; however, a deterioration in gait propulsion symmetry (%Δ: -5±2 %) and an increase in nonparetic propulsion (Δ: 0.9±0.3 %bw) were observed (p<0.05) after no-exosuit training. Conclusion: Soft robotic exosuits facilitate faster, longer duration, and higher intensity walking training associated with enhanced neuroplasticity.